ChloroquineV1, Main, Exploration, bibRecord, 003346

Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats

Identifieur interne : 003346 ( Main/Exploration ); précédent : 003345; suivant : 003347

Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats

Auteurs : W. Meerbach ; K. Gr Bner ; U. Müller ; W. Zimmermann

Source :

Experimental pathology [ 0232-1513 ] ; 1987.

RBID : ISTEX:3312A696AAC705AD5B8A5DDB98499BDBB23BE5A6

Descripteurs français

KwdFr :
- Animaux, Chloroquine (pharmacologie), Femelle, Grossesse, Imipramine (pharmacologie), Maturité foetale (), Phospholipides (métabolisme), Poumon (), Poumon (embryologie), Poumon (métabolisme), Rats, Taille d'organe (), Âge gestationnel.
MESH :
- embryologie : Poumon.
- métabolisme : Phospholipides, Poumon.
- pharmacologie : Chloroquine, Imipramine.
- Animaux, Femelle, Grossesse, Maturité foetale, Poumon, Rats, Taille d'organe, Âge gestationnel.

English descriptors

KwdEn :
- Animals, Chloroquine (pharmacology), Female, Fetal Organ Maturity (drug effects), Gestational Age, Imipramine (pharmacology), Lung (drug effects), Lung (embryology), Lung (metabolism), Organ Size (drug effects), Phospholipids (metabolism), Pregnancy, Rats, amphiphilic drugs, chloroquine, fetal lung, maturation, imipramine, lung, phospholipid content, newborn rat, phosphatidylcholine, phosphatidylglycerol, pneumocyte II, surfactant stimulation.
MESH :
- chemical , metabolism : Phospholipids.
- chemical , pharmacology : Chloroquine, Imipramine.
- drug effects : Fetal Organ Maturity, Lung, Organ Size.
- embryology : Lung.
- metabolism : Lung.
Teeft :
- Adult rats, Alveolar macrophages, Alveolar surfactant, Amphiphilic, Amphiphilic compounds, Amphiphilic drugs, Analogous results, Animals, Better aeration, Cationic amphiphilic drugs, Cesarean section, Chloroquine, Chloroquine cause, Chloroquine treatment, Control animals, Control groups, Direct influence, Disaturated phosphatidylcholine, Drug treatment, Dspc, Electron microscopy, Experimental group, Female, Fetal lung, Fetal lungs, Fetus, Generalized phospholipidosis, Gestation, Gestational Age, Gestational days, Imipramine, Imipramine treatment, Immature animals, Lamellar, Lamellar bodies, Lung lavage fluid, Lung structure, Lung weight, Moderate immaturity, Newborn, Newborn rats, Other hand, Pathol, Phospholipid content, Pneumocyte type, Pneumocytes, Pneumocytes type, Pregnancy, Premature development, Present study, Rats, Relative lung, Relative lung weight, Saline imipramine chloroquine, Surfactant, Survival rate.

Abstract

Summary: In continuation of previous experiments in adult rats (6) the alteration in content and composition of lung phospholipids (PL) and lung structure of newborn rats of different gestational age was studied after three administrations of the amphiphilic drugs imipramine (75 mg/kg b.w.) and chloroquine (50 mg/kg b.w.). The fetuses were obtained by Cesarean section on day 20, 21, or 22 of gestation.Morphological examinations of the lungs of drug treated 21-day-old fetuses revealed a substantially better aeration than nontreated controls. 20 and 22 days old fetuses showed no differences in aeration between drug and saline treated rats. Analogous results were obtained with respect to the 1 h survival rate of newborns. Furthermore, imipramine and chloroquine cause a premature development of the pneumocytes type II as shown by electron microscopy. An increased PL content as well as disaturated phosphatidylcholine (DSPC) and phosphatidylglycerol (PG) proportion of fetal lungs, especially in animals born on day 21 of gestation, were found after drug treatment.The results suggest an acceleration of maturation of the pneumocytes type II in fetal lungs induced by amphiphilic drugs.

Url:

https://api.istex.fr/ark:/67375/6H6-FLTDQV03-5/fulltext.pdf

DOI: 10.1016/S0232-1513(87)80032-4

Affiliations:

Le document en format XML

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<term>Female</term>
<term>Fetal Organ Maturity (drug effects)</term>
<term>Gestational Age</term>
<term>Imipramine (pharmacology)</term>
<term>Lung (drug effects)</term>
<term>Lung (embryology)</term>
<term>Lung (metabolism)</term>
<term>Organ Size (drug effects)</term>
<term>Phospholipids (metabolism)</term>
<term>Pregnancy</term>
<term>Rats</term>
<term>amphiphilic drugs</term>
<term>chloroquine</term>
<term>fetal lung, maturation</term>
<term>imipramine</term>
<term>lung, phospholipid content</term>
<term>newborn rat</term>
<term>phosphatidylcholine</term>
<term>phosphatidylglycerol</term>
<term>pneumocyte II</term>
<term>surfactant stimulation</term>
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<term>Chloroquine (pharmacologie)</term>
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<term>Grossesse</term>
<term>Imipramine (pharmacologie)</term>
<term>Maturité foetale ()</term>
<term>Phospholipides (métabolisme)</term>
<term>Poumon ()</term>
<term>Poumon (embryologie)</term>
<term>Poumon (métabolisme)</term>
<term>Rats</term>
<term>Taille d'organe ()</term>
<term>Âge gestationnel</term>
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<term>Imipramine</term>
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<term>Organ Size</term>
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<term>Poumon</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term>
<term>Imipramine</term>
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<term>Alveolar macrophages</term>
<term>Alveolar surfactant</term>
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<term>Amphiphilic compounds</term>
<term>Amphiphilic drugs</term>
<term>Analogous results</term>
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<term>Other hand</term>
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<term>Pneumocyte type</term>
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<term>Pneumocytes type</term>
<term>Pregnancy</term>
<term>Premature development</term>
<term>Present study</term>
<term>Rats</term>
<term>Relative lung</term>
<term>Relative lung weight</term>
<term>Saline imipramine chloroquine</term>
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<term>Grossesse</term>
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<front><div type="abstract">Summary: In continuation of previous experiments in adult rats (6) the alteration in content and composition of lung phospholipids (PL) and lung structure of newborn rats of different gestational age was studied after three administrations of the amphiphilic drugs imipramine (75 mg/kg b.w.) and chloroquine (50 mg/kg b.w.). The fetuses were obtained by Cesarean section on day 20, 21, or 22 of gestation.Morphological examinations of the lungs of drug treated 21-day-old fetuses revealed a substantially better aeration than nontreated controls. 20 and 22 days old fetuses showed no differences in aeration between drug and saline treated rats. Analogous results were obtained with respect to the 1 h survival rate of newborns. Furthermore, imipramine and chloroquine cause a premature development of the pneumocytes type II as shown by electron microscopy. An increased PL content as well as disaturated phosphatidylcholine (DSPC) and phosphatidylglycerol (PG) proportion of fetal lungs, especially in animals born on day 21 of gestation, were found after drug treatment.The results suggest an acceleration of maturation of the pneumocytes type II in fetal lungs induced by amphiphilic drugs.</div>
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Serveur d'exploration Chloroquine

Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats

Influence of imipramine and chloroquine on lung phospholipid content and lung structure in newborn rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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